Cost-effectiveness analysis of typhoid conjugate vaccines in an outbreak setting: a modeling study.

ABSTRACT:

Background

Several prolonged typhoid fever epidemics have been reported since 2010 throughout eastern and southern Africa, including Malawi, caused by multidrug-resistant Salmonella Typhi. The World Health Organization recommends the use of typhoid conjugate vaccines (TCVs) in outbreak settings; however, current data are limited on how and when TCVs might be introduced in response to outbreaks.

Methodology

We developed a stochastic model of typhoid transmission fitted to data from Queen Elizabeth Central Hospital in Blantyre, Malawi from January 1996 to February 2015. We used the model to evaluate the cost-effectiveness of vaccination strategies over a 10-year time horizon in three scenarios: (1) when an outbreak is likely to occur; (2) when an outbreak is unlikely to occur

SUBMITTER: Phillips MT 

PROVIDER: S-EPMC9993384 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature