Controlling the crystal structure of succinic acid via microfluidic spray-drying.

ABSTRACT: Many properties of materials, including their dissolution kinetics, hardness, and optical appearance, depend on their structure. Unfortunately, it is often difficult to control the structure of low molecular weight organic compounds that have a high propensity to crystallize if they are formulated from solutions wherein they have a high mobility. This limitation can be overcome by formulating these compounds within small airborne drops that rapidly dry, thereby limiting the time molecules have to arrange into the thermodynamically most stable phase. Such drops can be formed with a surface acoustic wave (SAW)-based spray-drier. In this paper, we demonstrate that the structure of a model low molecular weight compound relevant to applications in pharmacology and food, succinic acid, can be re

SUBMITTER: Okur AC 

PROVIDER: S-EPMC9993402 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature