The impact of age on antidepressant response: A mega-analysis of individuals with major depressive disorder.

ABSTRACT:

Introduction

Understanding how age affects antidepressant response in patients with major depressive disorder has been complicated by small and heterogeneous studies. Yet, understanding how age-across the lifespan-contributes to variation in response could inform treatment selection across the lifespan. This study sought to identify how age impacts antidepressant response using participant-level data from large, NIH-sponsored trials in individuals with MDD aged 12-74 years.

Materials and methods

Participant-level data were abstracted from three NIH-sponsored trials of pharmacotherapy (Treatment of SSRI-Resistant Depression in Adolescents (TORDIA) Study, Treatment of Adolescent Depression Study (TADS), and the Combining Medications to Enhance Depression Outcomes Study (COMED)

SUBMITTER: Strawn JR 

PROVIDER: S-EPMC9993423 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature