Advancing the Genetics of Lewy Body Disorders with Disease-Modifying Treatments in Mind.

ABSTRACT: In this article, a caveat for advancing the genetics of Lewy body disorders is raised, given the nosological controversy about whether to consider dementia with Lewy bodies (DLB) and Parkinson's disease (PD) as one entity or two separate entities. Using the framework of the sufficient and component causes model of causation, as further developed into an evolution-based model of causation, it is proposed that a disease of complex etiology is defined as having a relatively high degree of sharing of the component causes (a genetic or environmental factor), that is, a low degree of heterogeneity of the sufficient causes. Based on this definition, only if the sharing of component causes within each of two diseases is similar to their combined sharing can lumping be warranted. However, it is not

SUBMITTER: Levy G 

PROVIDER: S-EPMC9993470 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature