Indirect Mechanisms of Transcription Factor-Mediated Gene Regulation during Cell Fate Changes.

ABSTRACT: Transcription factors (TFs) are the master regulators of cellular identity, capable of driving cell fate transitions including differentiations, reprogramming, and transdifferentiations. Pioneer TFs recognize partial motifs exposed on nucleosomal DNA, allowing for TF-mediated activation of repressed chromatin. Moreover, there is evidence suggesting that certain TFs can repress actively expressed genes either directly through interactions with accessible regulatory elements or indirectly through mechanisms that impact the expression, activity, or localization of other regulatory factors. Recent evidence suggests that during reprogramming, the reprogramming TFs initiate opening of chromatin regions rich in somatic TF motifs that are inaccessible in the initial and final cellular states. It i

SUBMITTER: Larcombe MR 

PROVIDER: S-EPMC9993476 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature