Circulating levels of micronutrients and risk of infections: a Mendelian randomization study.

ABSTRACT:

Background

Micronutrients play an essential role at every stage of the immune response, and deficiencies can therefore lead to increased susceptibility to infections. Previous observational studies and randomized controlled trials of micronutrients and infections are limited. We performed Mendelian randomization (MR) analyses to evaluate the effect of blood levels of eight micronutrients (copper, iron, selenium, zinc, beta-carotene, vitamin B12, vitamin C, and vitamin D) on the risk of three infections (gastrointestinal infections, pneumonia, and urinary tract infections).

Methods

Two-sample MR was conducted using publicly available summary statistics from independent cohorts of European ancestry. For the three infections, we used data from UK Biobank and FinnGen. Inverse va

SUBMITTER: Flatby HM 

PROVIDER: S-EPMC9993583 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature