Geo-epidemiology of autoantibodies in rheumatoid arthritis: comparison between four ethnically diverse populations.

ABSTRACT:

Background

Rheumatoid arthritis (RA) occurs across the globe in different ethnic populations. Most RA patients harbor anti-modified protein antibodies (AMPA); however, it is unclear whether differences exist in autoantibody responses at different geographic locations and between different ethnic groups, which could provide new clues regarding factors underlying autoantibody development. We therefore investigated AMPA prevalence and association with HLA DRB1 alleles and smoking in four ethnically diverse populations on four different continents.

Methods

Anti-carbamylated (anti-CarP), anti-malondialdehyde acetaldehyde (anti-MAA), and anti-acetylated protein antibodies (anti-AcVim) IgG were determined in anti-citrullinated protein antibody-positive Dutch (NL, n = 103), Japanese

SUBMITTER: de Moel EC 

PROVIDER: S-EPMC9993621 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature