Molecular epidemiology of Bartonella quintana endocarditis in patients from Israel and Eastern Africa.

ABSTRACT:

Background

Bartonella quintana is an important cause of culture-negative endocarditis. Although humans have been considered as its only reservoir, recent studies showed that macaque species are also reservoirs of B. quintana. Based on multi-locus sequence typing (MLST) B. quintana strains have been classified into 22 sequence types (STs), with 7 STs exclusively found in humans. Data regarding the molecular epidemiology of B. quintana endocarditis is limited to only 3 STs identified in 4 patients from Europe and Australia. We studied B. quintana endocarditis acquired in Eastern Africa or Israel to investigate the genetic diversity and clinical relatedness of B. quintana from distinct geographic regions.

Methods

Eleven patients with B. quintana endocarditis, 6 from Eastern Afr

SUBMITTER: Sato S 

PROVIDER: S-EPMC9993625 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature