Cold-induced vasodilation response in a Japanese cohort: insights from cold-water immersion and genome-wide association studies.

ABSTRACT:

Background

Cold-induced vasodilation (CIVD) occurs after blood vessels in the skin are constricted due to local cold exposure. Although many CIVD studies have been conducted, the underlying molecular mechanisms are yet to be clarified. Therefore, we explored genetic variants associated with CIVD response using the largest-scale dataset reported to date in a CIVD study involving wavelet analysis; thus, the findings improve our understanding of the molecular mechanisms that regulate the CIVD response.

Methods

We performed wavelet analysis of three skin blood flow signals [endothelial nitric oxide (eNO)-independent, eNO-dependent, and neurogenic activities] during finger cold-water immersion at 5 °C in 94 Japanese young adults. Additionally, we conducted genome-wide association

SUBMITTER: Yasukochi Y 

PROVIDER: S-EPMC9993636 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature