Simplified within-host and Dose-response Models of SARS-CoV-2.

ABSTRACT: Understanding the mechanistic dynamics of transmission is key to designing more targeted and effective interventions to limit the spread of infectious diseases. A well-described within-host model allows explicit simulation of how infectiousness changes over time at an individual level. This can then be coupled with dose-response models to investigate the impact of timing on transmission. We collected and compared a range of within-host models used in previous studies and identified a minimally-complex model that provides suitable within-host dynamics while keeping a reduced number of parameters to allow inference and limit unidentifiability issues. Furthermore, non-dimensionalised models were developed to further overcome the uncertainty in estimates of the size of the susceptible cell pop

SUBMITTER: Xu J 

PROVIDER: S-EPMC9993737 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature