MicroRNA-627-5p inhibits colorectal cancer cell proliferation, migration and invasion by targeting Wnt2.

ABSTRACT:

Background

microRNA-627-5p (miR-627-5p) dysregulation has been observed in several cancer types, such as hepatocellular carcinoma, oral squamous cell carcinoma, glioblastoma multiforme, and gastric cancer. The biological function of miR-627-5p in colorectal cancer (CRC) growth and metastasis is yet unclear.

Aim

To investigate the effects of miR-627-5p on the malignant biological properties of colorectal malignant tumour cells by targeting Wnt2.

Methods

The levels of miR-627-5p in colorectal tumour tissues were assessed in Gene Expression Omnibus datasets. In order to identify Wnt2 transcript expression in CRC tissues, quantitative real-time polymerase chain reaction (qRT-PCR) analysis was used. Luciferase reporter tests were used to explore whether miR-627-5p might po

SUBMITTER: Zhao DY 

PROVIDER: S-EPMC9994042 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature