Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study.

ABSTRACT:

Introduction

To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition.

Methods

We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS).

Results

Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individu

SUBMITTER: Jiang X 

PROVIDER: S-EPMC9994160 | biostudies-literature | 2023 Jan-Mar

REPOSITORIES: biostudies-literature