Long-Term Exposure to Nitrate and Trihalomethanes in Drinking Water and Prostate Cancer: A Multicase-Control Study in Spain (MCC-Spain).

ABSTRACT:

Background

Nitrate and trihalomethanes (THMs) in drinking water are widespread and are potential human carcinogens.

Objective

We evaluated the association between drinking-water exposure to nitrate and THMs and prostate cancer.

Methods

During the period 2008-2013, 697 hospital-based incident prostate cancer cases (97 aggressive tumors) and 927 population-based controls were recruited in Spain, providing information on residential histories and type of water consumed. Average nitrate and THMs levels in drinking water were linked with lifetime water consumption to calculate waterborne ingestion. Odds ratios (OR) and 95% confidence intervals (CI) were estimated using mixed models with recruitment area as random effect. Effect modification by tumor grade (Gleason score),

SUBMITTER: Donat-Vargas C 

PROVIDER: S-EPMC9994181 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature