Vitamin B12 levels in thyroid disorders: A systematic review and meta-analysis.

ABSTRACT:

Background and aims

Numerous studies have found an association between vitamin deficiency and thyroid disorders (TD). The presence of anti-parietal cell antibodies is indicative of reduced ability to absorb vitamin B12. Thus, this study reviewed the existing studies with the objective of assessing differences in the serum levels of vitamin B12 among patients with and without TD, the frequency of vitamin B12 deficiency in patients with TD, and the presence of anti-parietal cell antibodies in patients with TD.

Methods

A meta-analysis of random-effects model was conducted to calculate pooled frequencies, mean differences (MD), and their respective 95% confidence intervals (CI). We identified 64 studies that met our inclusion criteria (n = 28597).

Results

We found that pa

SUBMITTER: Benites-Zapata VA 

PROVIDER: S-EPMC9994182 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature