Untargeted serum metabolomic analysis reveals a role for purinergic signaling in FPIES.

ABSTRACT:

Background

Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy with a typical onset in infancy. Its symptoms are distinct from those of IgE-mediated food allergies and include severe repetitive vomiting, lethargy, and pallor. FPIES reactions are associated with T_H17 cytokines and a systemic innate immune activation; however, the link between immune activation and symptoms is poorly understood.

Objective

Our aim was to use an untargeted metabolomics approach to identify novel pathways associated with FPIES reactions.

Methods

Serum samples were obtained before, during, and after oral food challenge (OFC) (10 subjects with FPIES and 10 asymptomatic subjects), and they were analyzed by untargeted metabolomics. Two-way ANOVA wi

SUBMITTER: Lozano-Ojalvo D 

PROVIDER: S-EPMC9994238 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature