Reducing ischemic kidney injury through application of a synchronization modulation electric field to maintain Na⁺/K⁺-ATPase functions.

ABSTRACT: Renal ischemia-reperfusion injury is an important contributor to the development of delayed graft function after transplantation, which is associated with higher rejection rates and poorer long-term outcomes. One of the earliest impairments during ischemia is Na⁺/K⁺-ATPase (Na/K pump) dysfunction due to insufficient ATP supply, resulting in subsequent cellular damage. Therefore, strategies that preserve ATP or maintain Na/K pump function may limit the extent of renal injury during ischemia-reperfusion. Here, we applied a synchronization modulation electric field to activate Na/K pumps, thereby maintaining cellular functions under ATP-insufficient conditions. We tested the effectiveness of this technique in two models of ischemic renal injury: an in situ renal ischemia

SUBMITTER: Chen W 

PROVIDER: S-EPMC9994383 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature