HPV genotypes in high-grade cervical lesions and invasive cervical carcinoma detected in Gabonese women.

ABSTRACT:

Background

Cervical cancer is the third most common cancer among women worldwide, but particularly affects women living in sub-Saharan Africa. Screening and vaccination programs are two prevention approaches that can reduce cervical cancer incidence. However, effective vaccination campaigns require better knowledge of the prevalence of the main human papillomavirus (HPV) genotypes reported in high-grade neoplastic lesions and invasive carcinomas in women.

Methods

All samples collected in this study were processed using standard histopathological methods with haematoxylin and eosin staining of the sections. Areas with abnormal cells were then identified. The HPV genotype was determined on the DNA extracted from the same sections using nested PCR followed by amplicon sequencin

SUBMITTER: Moussavou-Boundzanga P 

PROVIDER: S-EPMC9994388 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature