Benzodiazepine use and risk of recurrence in bipolar disorder: a STEP-BD report.

ABSTRACT:

Objective

Benzodiazepines are widely prescribed to patients with bipolar disorder, but their impact on relapse and recurrence has not been examined.

Method

We examined prospective data from a cohort of DSM-IV bipolar I and II patients who achieved remission during evidence-guided naturalistic treatment in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study (conducted in the United States between 1999 and 2005). Risk for recurrence among individuals who did or did not receive benzodiazepine treatment was examined using survival analysis. Cox regression was used to adjust for clinical and sociodemographic covariates. Propensity score analysis was used in a confirmatory analysis to address the possible impact of confounding variables.

Results

SUBMITTER: Perlis RH 

PROVIDER: S-EPMC9994436 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature