The global regulator FpLaeB is required for the regulation of growth, development, and virulence in Fusarium pseudograminearum.

ABSTRACT: Fusarium pseudograminearum is a soil-borne pathogen that is capable of causing a highly destructive crown disease in wheat. Secondary metabolites (SMs), especially deoxynivalenol (DON), are the primary virulence factors during infection. Here, we characterised the global regulator FpLaeB, an orthologue of LaeB protein function, to regulate the SM in Aspergillus nidulans. Through the utility of the gene targeting approach, we found that the vegetative growth of the FpLaeB deletion mutant was drastically reduced compared to that of the wild type. FpLaeB was also important for conidiation because the FpLaeB deletion mutant formed fewer conidia in induced medium. In addition, the sensitivity of the FpLaeB deletion mutant to the cell wall integri

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9994621 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature