Increased platelet activation and lower platelet-monocyte aggregates in COVID-19 patients with severe pneumonia.

ABSTRACT:

Background

The increased procoagulant platelets and platelet activation are associated with thrombosis in COVID-19. In this study, we investigated platelet activation in COVID-19 patients and their association with other disease markers.

Methods

COVID-19 patients were classified into three severity groups: no pneumonia, mild-to-moderate pneumonia, and severe pneumonia. The expression of P-selectin and activated glycoprotein (aGP) IIb/IIIa on the platelet surface and platelet-leukocyte aggregates were measured prospectively on admission days 1, 7, and 10 by flow cytometry.

Results

P-selectin expression, platelet-neutrophil, platelet-lymphocyte, and platelet-monocyte aggregates were higher in COVID-19 patients than in uninfected control individuals. In contrast, aGPIIb/

SUBMITTER: Srihirun S 

PROVIDER: S-EPMC9994685 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature