A Nationwide Prospective Clinical Trial on Active Surveillance in Patients With Non-intraabdominal Desmoid-type Fibromatosis: The GRAFITI Trial.

ABSTRACT:

Objective

To assess tumor behavior and the efficacy of active surveillance (AS) in patients with desmoid-type fibromatosis (DTF).

Summary of background data

AS is recommended as initial management for DTF patients. Prospective data regarding the results of AS are lacking.

Methods

In this multicenter prospective cohort study (NTR4714), adult patients with non-intraabdominal DTF were followed during an initial AS approach for 3 years. Tumor behavior was evaluated according to Response Evaluation Criteria in Solid Tumors. Cumulative incidence of the start of an active treatment and progression-free survival (PFS) were calculated using the Kaplan-Meier method. Factors predictive for start of active treatment were assessed by Cox regression analyses.

Results

A total

SUBMITTER: Schut AW 

PROVIDER: S-EPMC9994811 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature