Broadly neutralizing antibody-mediated protection against SHIV infection among macaques with vaginal sexually transmitted infections.

ABSTRACT:

Objective

Sexually transmitted infections (STIs) increase mucosal HIV infection risk and have the potential to reduce preexposure prophylaxis efficacy. Clinical trials of a broadly neutralizing antibody (bNAb) provided proof-of-concept that passive immunization against HIV can be efficacious in people. We sought to evaluate preclinically the protective efficacy of passive bNAb immunization against simian-human immunodeficiency virus (SHIV) infection in the context of concurrent vaginal STIs.

Design

Using a macaque model of combined ulcerative and nonulcerative vaginal STIs caused by Treponema pallidum , Chlamydia trachomatis , and Trichomonas vaginalis , we determined the protection that passively administered bNAb 10-1074 conferred against repeated vaginal SHIV challenges a

SUBMITTER: Garber DA 

PROVIDER: S-EPMC9994845 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature