Lower anti-mullerian hormone levels are associated with HIV in reproductive age women and shorter leukocyte telomere length among late reproductive age women.

ABSTRACT:

Objectives

We sought to better understand factors associated with ovarian aging in women living with HIV (WLWH).

Design

HIV has been associated with diminished fertility, younger age at menopause, and shorter leukocyte telomere length (LTL), a marker of cellular aging. We herein examine cross-sectional and longitudinal associations between LTL, Anti-Mullerian hormone (AMH), and HIV.

Methods

We included WLWH and HIV-negative women 12-50 years of age in the CARMA cohort with ≥ 1 study visit(s). LTL and AMH were measured by qPCR and ELISA, respectively. Women were analysed in peak reproductive (<35 years) vs. late reproductive (≥35 years) life phases. Using multivariable mixed-effect linear or logistic regressions, we assessed factors associated with AMH and ΔAMH/year wh

SUBMITTER: Van Ommen CE 

PROVIDER: S-EPMC9994852 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature