High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex.

ABSTRACT: The characterization of cortical myelination is essential for the study of structure-function relationships in the human brain. However, knowledge about cortical myelination is largely based on post-mortem histology, which generally renders direct comparison to function impossible. The repeating pattern of pale-thin-pale-thick stripes of cytochrome oxidase (CO) activity in the primate secondary visual cortex (V2) is a prominent columnar system, in which histology also indicates different myelination of thin/thick versus pale stripes. We used quantitative magnetic resonance imaging (qMRI) in conjunction with functional magnetic resonance imaging (fMRI) at ultra-high field strength (7 T) to localize and study myelination of stripes in four human participants at sub-millimeter resolution in v

SUBMITTER: Haenelt D 

PROVIDER: S-EPMC9995117 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature