Therapeutic effects of Panax notoginseng saponins in rheumatoid arthritis: network pharmacology and experimental validation.

ABSTRACT: Panax notoginseng saponins (PNS) have been reported to have good anti-inflammatory effects. However, the anti-inflammatory effect mechanism in rheumatoid arthritis (RA) remains unknown. The focus of this research was to investigate the molecular mechanism of PNS in the treatment of RA. The primary active components of PNS were tested utilizing the Traditional Chinese Medicine Systems Pharmacology Database (TCMSP) and Analysis Platform based on oral bioavailability and drug-likeness. The target databases for knee osteoarthritis were created using GeneCards and Online Mendelian Inheritance in Man (OMIM). The visual interactive network structure 'active component - action target - illness' was created using Cytoscape software. A protein interaction network was built, and associated pro

SUBMITTER: Ma X 

PROVIDER: S-EPMC9995134 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature