Urine and Plasma Markers of Platelet Activation and Respiratory Symptoms in COPD.

ABSTRACT:

Introduction

Antiplatelet therapy has been associated with fewer exacerbations and reduced respiratory symptoms in chronic obstructive pulmonary disease (COPD). Whether platelet activation is associated with respiratory symptoms in COPD is unknown.

Methods

Former smokers with spirometry-confirmed COPD had urine 11-dehydro-thromboxane B2 (11dTxB2), plasma soluble CD40L (sCD40L), and soluble P-selectin (sP-selectin) repeatedly measured during a 6- to 9-month study period. Multivariate mixed-effects models adjusted for demographics, clinical characteristics, and medication use evaluated the association of each biomarker with respiratory symptoms, health status, and quality of life.

Results

Among 169 participants (average age 66.5±8.2 years, 51.5% female, 47.5±31 pack yea

SUBMITTER: Fawzy A 

PROVIDER: S-EPMC9995228 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature