Premature T cell aging in major depression: A double hit by the state of disease and cytomegalovirus infection.

ABSTRACT:

Introduction

Previous research indicates that premature T cell senescence is a characteristic of major depressive disorder (MDD). However, known senescence inducing factors like cytomegalovirus (CMV) infection or, probably, childhood adversity (CA) have not been taken into consideration so far.

Objective

Differentiation and senescent characteristics of T cells of MDD patients were investigated in relation to healthy controls (HC), taking the CMV seropositivity and CA into account.

Methods

127 MDD and 113 HC of the EU-MOODSTRATIFICATION cohort were analyzed. Fluorescence activated cell sorting (FACS) analysis was performed to determine B, NK, and T cell frequencies. In a second FACS analysis, naïve, effector memory (Tem), central memory (Tcm), effector memory cells re-

SUBMITTER: Simon MS 

PROVIDER: S-EPMC9995284 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature