Ethoxy acetalated dextran nanoparticles for drug delivery: A comparative study of formulation methods.

ABSTRACT: Dextran-based polymers, such as ethoxy acetalated dextran (Ace-DEX), are increasingly becoming the focus of research as they offer great potential for the development of polymer-based nanoparticles as drug delivery vehicles. Their major advantages are the facile synthesis, straightforward particle preparation and the pH-dependent degradation of the particles that can be fine-tuned by the degree of acetalation of the polymer. In this study we have shown that Ace-DEX can not only compete against the commonly used and FDA-approved polymer poly(lactic-co-glycolic acid) (PLGA), but even has the potential to outperform it in its encapsulation properties, e.g., for the herein used anti-inflammatory leukotriene biosynthesis inhibitor BRP-187. We used three different methods (microflu

SUBMITTER: Behnke M 

PROVIDER: S-EPMC9995288 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature