Prophylactic and curative effects of Carica papaya Linn. pulp extract against carbon tetrachloride-induced hepatotoxicity in male rats.

ABSTRACT: Several chemicals and medications induce cellular damage in various organs of the body by activating reactive substances' metabolism leading to various pathological conditions including liver disease. In this study, we evaluated the prophylactic and curative effects of Carica papaya Linn. pulp water extract (PE) against CCl₄-induced rat hepatotoxicity. Five groups of rats were created, control, PE, CCl₄, (PE-CCl₄): The rats were administered with PE pre and during CCl₄ injection, and (PE-CCl₄-PE): The rats were administered with PE pre, during, and after CCl₄. The markers of oxidative stress ("OS": oxidant and antioxidants), inflammation [nuclear factor-κB, tumor necrosis factor-α, and interleukin-6], fibrosis [transforming

SUBMITTER: Shaban NZ 

PROVIDER: S-EPMC9995559 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature