Transcriptional reprogramming of natural killer cells by vaccinia virus shows both distinct and conserved features with mCMV.

ABSTRACT: Natural killer (NK) cells have an established role in controlling poxvirus infection and there is a growing interest to exploit their capabilities in the context of poxvirus-based oncolytic therapy and vaccination. How NK cells respond to poxvirus-infected cells to become activated is not well established. To address this knowledge gap, we studied the NK cell response to vaccinia virus (VACV) in vivo, using a systemic infection murine model. We found broad alterations in NK cells transcriptional activity in VACV-infected mice, consistent with both direct target cell recognition and cytokine exposure. There were also alterations in the expression levels of specific NK surface receptors (NKRs), including the Ly49 family and SLAM receptors, as well as upregulation of memory-associated

SUBMITTER: Depierreux DM 

PROVIDER: S-EPMC9995584 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature