Altered infective competence of the human gut microbiome in COVID-19.

ABSTRACT:

Background

Infections with SARS-CoV-2 have a pronounced impact on the gastrointestinal tract and its resident microbiome. Clear differences between severe cases of infection and healthy individuals have been reported, including the loss of commensal taxa. We aimed to understand if microbiome alterations including functional shifts are unique to severe cases or a common effect of COVID-19. We used high-resolution systematic multi-omic analyses to profile the gut microbiome in asymptomatic-to-moderate COVID-19 individuals compared to a control group.

Results

We found a striking increase in the overall abundance and expression of both virulence factors and antimicrobial resistance genes in COVID-19. Importantly, these genes are encoded and expressed by commensal taxa from famil

SUBMITTER: de Nies L 

PROVIDER: S-EPMC9995755 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature