Phenotypic divergence in sleep and circadian cycles linked by affective state and environmental risk related to psychosis.

ABSTRACT:

Study objectives

Environmental cues influence circadian rhythm timing and neurochemicals involved in the regulation of affective behavior. How this interplay makes them a probable nonspecific risk factor for psychosis is unclear. We aimed to identify the relationship between environmental risk for psychosis and circadian timing phenotypes sampled from the general population.

Methods

Using an online survey, we devised a cumulative risk exposure score for each of the 1898 survey respondents based on 23 empirically verified transdiagnostic risks for psychosis, three dimensions of affect severity, psychotic-like experiences, and help-seeking behavior. Quantitative phenotyping of sleep and circadian rhythms was undertaken using at-home polysomnography, melatonin and cortisol prof

SUBMITTER: Purple RJ 

PROVIDER: S-EPMC9995776 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature