Sleep architecture is associated with core symptom severity in autism spectrum disorder.

ABSTRACT:

Study objectives

While caregiver-reported sleep disturbances are common in children and adolescents with autism spectrum disorder (['), few studies have measured objective sleep in ASD compared to controls, and their findings are mixed. We investigated (1) differences in sleep architecture, specifically slow-wave sleep (SWS) and rapid eye movement (REM) sleep, between ASD and typically developing controls (TD); and (2) if any observed differences in sleep were associated with core ASD symptoms.

Methods

We used ambulatory polysomnography (PSG) in 53 participants with ASD (ages 4-18) and 66 age-matched TD in their home sleeping environment. The primary outcome measures were SWS and REM sleep. Core behavioral ASD symptoms were assessed using the Autism Diagnostic Interview-Revi

SUBMITTER: Kawai M 

PROVIDER: S-EPMC9995925 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature