Co-expression network of mRNA and DNA methylation in first-episode and drug-naive adolescents with major depressive disorder.

ABSTRACT:

Objective

We explored the DNA methylation and messenger RNA (mRNA) co-expression network and hub genes in first-episode, drug-naive adolescents with major depressive disorder (MDD). To preliminarily explore whether adolescent MDD has unique mechanisms compared with adult MDD.

Methods

We compared DNA methylation and mRNA profiles of peripheral blood mononuclear cells from four first-episode and drug-naive adolescents with MDD and five healthy adolescent controls (HCs). We performed differential expression analysis, constructed co-expression network, and screened the hub genes. And enrichment analysis was performed based on Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG). We also downloaded DNA methylation and mRNA datasets of adults with MDD (GSE113725/G

SUBMITTER: Tao Y 

PROVIDER: S-EPMC9995926 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature