Ligand-based pharmacophore modeling and QSAR approach to identify potential dengue protease inhibitors.

ABSTRACT: The viral disease dengue is transmitted by the Aedes mosquito and is commonly seen to occur in the tropical and subtropical regions of the world. It is a growing public health concern. To date, other than supportive treatments, there are no specific antiviral treatments to combat the infection. Therefore, finding potential compounds that have antiviral activity against the dengue virus is essential. The NS2B-NS3 dengue protease plays a vital role in the replication and viral assembly. If the functioning of this protease were to be obstructed then viral replication would be halted. As a result, this NS2B-NS3 proves to be a promising target in the process of anti-viral drug design. Through this study, we aim to provide suggestions for compounds that may serve as potent inhibitors of the deng

SUBMITTER: Poola AA 

PROVIDER: S-EPMC9996041 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature