Causal effects of fatty acids on atopic dermatitis: A Mendelian randomization study.

ABSTRACT:

Background

Some evidence suggests abnormalities in fatty acids in patients with atopic dermatitis (AD), and benefits of supplementation with these fatty acids have been reported. However, there is still substantial controversy on the correlation between fatty acids and AD. Therefore, the aim of this study was to determine whether fatty acid levels are causally related to AD using a Mendelian randomization approach.

Methods

We evaluated the data about the fatty acids levels and AD with various methods from Genome-Wide Association Study (GWAS). GWAS results were available both from European ancestry. Mendelian randomization methods were used to analysis the casual inference of fatty acids on AD. MR Egger and MR-PRESSO were used to determine pleiotropy and heterogeneity. Furthe

SUBMITTER: Lin JY 

PROVIDER: S-EPMC9996175 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature