Interleukin-3 protects against viral pneumonia in sepsis by enhancing plasmacytoid dendritic cell recruitment into the lungs and T cell priming.

ABSTRACT:

Rationale

Sepsis, a global health burden, is often complicated by viral infections leading to increased long-term morbidity and mortality. Interleukin-3 (IL-3) has been identified as an important mediator amplifying acute inflammation in sepsis; however, its function in the host response to viral infections during sepsis remains elusive.

Objectives

To investigate the role of IL-3 during viral pneumonia in sepsis.

Methods

We included septic patients from two different cohorts and used in vitro and in vivo assays. The obtained data were substantiated using a second model (SARS-CoV-2 infections).

Measurements and main results

Low plasma IL-3 levels were associated with increased herpes simplex virus (HSV) airway infections in septic patients, resulti

SUBMITTER: Benard A 

PROVIDER: S-EPMC9996195 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature