Inflammatory and insulinemic dietary patterns and risk of endometrial cancer among US women.

ABSTRACT:

Background

Although unopposed estrogen exposure is considered a major driver of endometrial carcinogenesis, chronic inflammation and insulin resistance and hyperinsulinemia are also major endometrial cancer risk factors. However, it is unclear whether diets with inflammatory or insulinemic potential are associated with risk of endometrial cancer.

Methods

We followed 48 330 women from the Nurses' Health Study (1984-2016) and 85 426 women from the Nurses' Health Study II (1989-2017). Using food frequency questionnaires, we calculated repeated measures of empirical dietary inflammatory pattern (EDIP) and empirical dietary index for hyperinsulinemia (EDIH) scores, which characterize the potential of the whole diet to modulate circulating biomarkers of inflammation or C-peptide,

SUBMITTER: Romanos-Nanclares A 

PROVIDER: S-EPMC9996217 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature