Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival.

ABSTRACT: Genetic alterations in cancer cells trigger oncogenic transformation, a process largely mediated by the dysregulation of kinase and transcription factor (TF) activities. While the mutational profiles of thousands of tumours have been extensively characterised, the measurements of protein activities have been technically limited until recently. We compiled public data of matched genomics and (phospho)proteomics measurements for 1,110 tumours and 77 cell lines that we used to estimate activity changes in 218 kinases and 292 TFs. Co-regulation of kinase and TF activities reflects previously known regulatory relationships and allows us to dissect genetic drivers of signalling changes in cancer. We find that loss-of-function mutations are not often associated with the dysregulation of downstrea

SUBMITTER: Sousa A 

PROVIDER: S-EPMC9996241 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature