Strain-specific responsiveness of hepatitis D virus to interferon-alpha treatment.

ABSTRACT:

Background & aims

Pegylated interferon alpha (pegIFNα) is commonly used for the treatment of people infected with HDV. However, its mode of action in HDV-infected cells remains elusive and only a minority of people respond to pegIFNα therapy. Herein, we aimed to assess the responsiveness of three different cloned HDV strains to pegIFNα. We used a previously cloned HDV genotype 1 strain (dubbed HDV-1a) that appeared insensitive to interferon-α in vitro, a new HDV strain (HDV-1p) we isolated from an individual achieving later sustained response to IFNα therapy, and one phylogenetically distant genotype 3 strain (HDV-3).

Methods

PegIFNα was administered to human liver chimeric mice infected with HBV and the different HDV strains or to HBV/HDV infected human hepato

SUBMITTER: Giersch K 

PROVIDER: S-EPMC9996322 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature