Revealing the importance of prenatal gut microbiome in offspring neurodevelopment in humans.

ABSTRACT:

Background

It has been widely recognized that a critical time window for neurodevelopment occurs in early life and the host's gut microbiome plays an important role in neurodevelopment. Following recent demonstrations that the maternal prenatal gut microbiome influences offspring brain development in murine models, we aim to explore whether the critical time window for the association between the gut microbiome and neurodevelopment is prenatal or postnatal for human.

Methods

Here we leverage a large-scale human study and compare the associations between the gut microbiota and metabolites from mothers during pregnancy and their children with the children's neurodevelopment. Specifically, using multinomial regression integrated in Songbird, we assessed the discriminating power

SUBMITTER: Sun Z 

PROVIDER: S-EPMC9996363 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature