Identification of the miRNAome in human fracture callus and nonunion tissues.

ABSTRACT:

Background

Nonunions remain a challenging post-traumatic complication that often leads to a financial and health burden that affects the patient's quality of life. Despite a wealth of knowledge about fracture repair, especially gene and more recently miRNA expression, much remains unknown about the molecular differences between normal physiological repair (callus tissue) and a nonunion. To probe this lack of knowledge, we embarked on a study that sought to identify and compare the human miRNAome of normal bone to that present in a normal fracture callus and those from two different classic nonunion types, hypertrophic and oligotrophic.

Methods

Normal bone and callus tissue samples were harvested during revision surgery from patients with physiological fracture repair and non

SUBMITTER: Hadjiargyrou M 

PROVIDER: S-EPMC9996375 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature