Timing of Antidepressant Discontinuation During Pregnancy and Postpartum Psychiatric Outcomes in Denmark and Norway.

ABSTRACT:

Importance

Approximately one-half of women treated for affective disorders discontinue antidepressant use during pregnancy, yet this discontinuation could lead to relapse post partum.

Objective

To investigate the associations between longitudinal antidepressant fill trajectories during pregnancy and postpartum psychiatric outcomes.

Design, setting, and participants

This cohort study used nationwide registers in Denmark and Norway. The sample included 41 475 live-born singleton pregnancies in Denmark (1997-2016) and 16 459 in Norway (2009-2018) for women who filled at least 1 antidepressant prescription within 6 months before pregnancy.

Exposures

Antidepressant prescription fills were obtained from the prescription registers. Antidepressant treatment during preg

SUBMITTER: Trinh NTH 

PROVIDER: S-EPMC9996461 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature