SARS-CoV-2 mRNA vaccines decouple anti-viral immunity from humoral autoimmunity.

ABSTRACT: mRNA-based vaccines dramatically reduce the occurrence and severity of COVID-19, but are associated with rare vaccine-related adverse effects. These toxicities, coupled with observations that SARS-CoV-2 infection is associated with autoantibody development, raise questions whether COVID-19 vaccines may also promote the development of autoantibodies, particularly in autoimmune patients. Here we used Rapid Extracellular Antigen Profiling to characterize self- and viral-directed humoral responses after SARS-CoV-2 mRNA vaccination in 145 healthy individuals, 38 patients with autoimmune diseases, and 8 patients with mRNA vaccine-associated myocarditis. We confirm that most individuals generated robust virus-specific antibody responses post vaccination, but that the quality of this response is i

SUBMITTER: Jaycox JR 

PROVIDER: S-EPMC9996559 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature