Administration of macrolide antibiotics increases cardiovascular risk.

ABSTRACT:

Background

The increased risk of cardiovascular events in patients prescribed macrolides has been subject to debate for decades.

Methods

Medline, EMBASE databases and ClinicalTrials.gov were searched from inception until August 31, 2022 for studies investigating the link between macrolides and cardiovascular risk. A meta-analysis was performed using a random-effects model.

Results

A total of 80 studies involving 39,374,874 patients were included. No association was found between macrolides and all-cause death. However, compared with the non-macrolide group, macrolides were associated with a significantly increased risk of ventricular arrhythmia or sudden cardiac death (VA or SCD) (azithromycin, relative ratio [RR]: 1.53; 95% confidence interval [CI]: 1.19 to 1.97; cla

SUBMITTER: Wu Y 

PROVIDER: S-EPMC9996752 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature