Inhaled anti-TSLP antibody fragment, ecleralimab, blocks responses to allergen in mild asthma.

ABSTRACT:

Background

Thymic stromal lymphopoietin (TSLP) is a key upstream regulator driving allergic inflammatory responses. We evaluated the efficacy and safety of ecleralimab, a potent inhaled neutralising antibody fragment against human TSLP, using allergen inhalation challenge (AIC) in subjects with mild atopic asthma.

Methods

This was a 12-week, randomised, double-blind, placebo-controlled, parallel-design, multicentre allergen bronchoprovocation study conducted at 10 centres across Canada and Germany. Subjects aged 18-60 years with stable mild atopic asthma were randomised (1:1) to receive 4 mg once-daily inhaled ecleralimab or placebo. Primary end-points were the allergen-induced change in forced expiratory volume in 1 s (FEV₁) during the late asthmatic response (LA

SUBMITTER: Gauvreau GM 

PROVIDER: S-EPMC9996823 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature