Peripheral inflammation in behavioural variant frontotemporal dementia: associations with central degeneration and clinical measures.

ABSTRACT:

Background

Neuroinflammation plays a significant role in the progression of frontotemporal dementia (FTD). However, the association between peripheral inflammatory factors and brain neurodegeneration is poorly understood. We aimed to examine changes in peripheral inflammatory markers in patients with behavioural variant FTD (bvFTD) and explore the potential association between peripheral inflammation and brain structure, metabolism, and clinical parameters.

Methods

Thirty-nine bvFTD patients and 40 healthy controls were enrolled and underwent assessment of plasma inflammatory factors, positron emission tomography/magnetic resonance imaging, and neuropsychological assessments. Group differences were tested using Student's t test, Mann‒Whitney U test, or ANOVA. Partial correla

SUBMITTER: Chu M 

PROVIDER: S-EPMC9996857 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature