Equine osteoarthritis modifies fatty acid signatures in synovial fluid and its extracellular vesicles.

ABSTRACT:

Background

Individual fatty acids (FAs) and their derivatives (lipid mediators) with pro-inflammatory or dual anti-inflammatory and pro-resolving properties have potential to influence the health of joint tissues. Osteoarthritis (OA) is an age-associated chronic joint disease that can be featured with altered FA composition in the synovial fluid (SF) of human patients. The counts and cargo of extracellular vesicles (EVs), membrane-bound particles released by synovial joint cells and transporting bioactive lipids, can also be modified by OA. The detailed FA signatures of SF and its EVs have remained unexplored in the horse - a well-recognized veterinary model for OA research.

Methods

The aim of the present study was to compare the FA profiles in equine SF and its ultracentrif

SUBMITTER: Mustonen AM 

PROVIDER: S-EPMC9996872 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature