Lung versus gut exposure to air pollution particles differentially affect metabolic health in mice.

ABSTRACT:

Background

Air pollution has emerged as an unexpected risk factor for diabetes. However, the mechanism behind remains ill-defined. So far, the lung has been considered as the main target organ of air pollution. In contrast, the gut has received little scientific attention. Since air pollution particles can reach the gut after mucociliary clearance from the lungs and through contaminated food, our aim was to assess whether exposure deposition of air pollution particles in the lung or the gut drive metabolic dysfunction in mice.

Methods

To study the effects of gut versus lung exposure, we exposed mice on standard diet to diesel exhaust particles (DEP; NIST 1650b), particulate matter (PM; NIST 1649b) or phosphate-buffered saline by either intratracheal instillation (30 µg 2 day

SUBMITTER: Bosch AJT 

PROVIDER: S-EPMC9996885 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature