Inflammation and neuronal gene expression changes differ in early versus late chronic traumatic encephalopathy brain.

ABSTRACT:

Background

Our understanding of the molecular underpinnings of chronic traumatic encephalopathy (CTE) and its associated pathology in post-mortem brain is incomplete. Factors including years of play and genetic risk variants influence the extent of tau pathology associated with disease expression, but how these factors affect gene expression, and whether those effects are consistent across the development of disease, is unknown.

Methods

To address these questions, we conducted an analysis of the largest post-mortem brain CTE mRNASeq whole-transcriptome dataset available to date. We examined the genes and biological processes associated with disease by comparing individuals with CTE with control individuals with a history of repetitive head impacts that lack CTE pathology. We

SUBMITTER: Labadorf A 

PROVIDER: S-EPMC9996917 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature